Published papers (2013)
1. V-K-W Wong, T Li, B-Y-K Law, E-D-L Ma, N-C Yip,F Michelangeli, C-K-M Law, M-M Zhang, K-Y-C Lam, P-L Chan and L Liu. Saikosaponin-d, a novel SERCA inhibitor induces autophagic cell death in apoptosis-defective cells.Cell Death Differ. In Press.
2. S Sun, Y-Z Yan, P-S Xie and C-W-K Lam. Analysis of bioactive fraction of caulis stauntonia by HPLC fingerprinting.J Liq Chromatogr R T.In Press.
3. L-P Bai, A-H-M Ho, D-L Ma, H Yang, W-C Fu and Z-H Jiang. Amino glycosylation can enhance the G-quadruplex binding activity of epigallocatechin.PLoS One. In Press
4. T Niu, D-L Smith, Z Yang, S Gao, T-J Yin, Z-H Jiang, M You, R-A Gibbs, J-F Petrosino and M Hu. Bioactivity and bioavailability of ginsenosides are dependent on the glycosidase activities of the A/J mouse intestinal microbiome defined by pyrosequencing.Pharmaceutical Research. In Press
5. L Xiao, T Yi and Y Liu. A new self-microemulsifying mouth dissolving film to improve the oral bioavailability of poorly water soluble drugs.Drug DevInd Pharm.In Press
6. W-J Zhang, Y Lan, Q-L Huang and Z-C Hua. Galangin induces B16F10 melanoma cell apoptosis via mitochondrial pathway and sustained activation of p38 MAPK.Cytotechnology. In Press
7. H-Q Zhuang, W-W Jiang, X-Y Zhang, F Qiu, Z-Y Gan, W Cheng, J Zhang, S-W Guan, B Tang, Q-L Huang, X-H Wu, X-F Huang, W-H Jiang, Q-G Hu, M Lu and Z-C Hua. Suppression of HSP70 expression sensitizes NSCLC cell lines to TRAIL-induced apoptosis by upregulating DR4 and DR5 and downregulating c-FLIP-L expressions.J Mol Med (Berl). In Press
8. S-H Chui, Y-H Wong, H-I Chio, M-Y Fong, Y-M Chiu, Y-T Szeto, W-T Vong and C-W-K Lam. Study of heavy metal poisoning in frequent users of Chinese medicines in Hong Kong and Macau.Phytother Res. In Press
9. E-L-H Leung, Z-W Cao, Z-H Jiang, H Zhau and L Liu. Network-based drug discovery by integrating systems biology and computational technologies.Brief Bioinform.
10. M Hu, W Lan, C-W-K Lam, Y-T Mak, C-P Pang and B Tomlinson. Heterozygous familial hypercholesterolemia in Hong Kong Chinese. Study of 252 cases.Int J Cardiol.
11. W-H Tam, R-C Ma, X Yang, G-T Ko, D-S Sohota, M-H Chan, C-W-K Lam, C-S Cockram and J-C Chan. Prediction of women’s long-term cardiometabolic risks using glycemic indices during pregnancy.J Obstet Gymaecol Res.2013;39(2):484-491.
12. C-K Wong, K-M Lau, I-H-S Chan, S-Q Hu, Y-Y-O Lam, A-O-K Choi and C-W-K Lam. MicroRNA-21* regulates the prosurvival effect of GM-CSF on human eosinophils.Immunobiology. 2013;2018(2):255-262.
13. J-G Lu, L Zhu, K-Y-W Lo, A-K-M Leung, H-M Ho, Z-Z Zhao, W-F Fong, H-Y Zhang and Z-H Jiang. Chemical differentiation of two taste variants of gynostemma pentaphyllum by using UPLC-Q-TOF-MS and HPLC-ELSD.J Agrc Food Chem.2013;61(1):90-97.
14. L Li, T Yi and C-W-K Lam. Effects of spray-drying and choice of solid carriers on concentrations of Labrasol and Transcutol in solid self-microemulsifying drug delivery systems.Molecules. 2013;18(1):545-560.
15. W-J Zhang, B Tang, Q-L Huang and Z-C Hua. Galangin inhibits tumour growth and metastasis of B16F10 melanoma.J Cell Biochem. 2013;114(1):152-161.
16. Ichihara K, Ceriotti F, Tam TH, Sueyoshi S, Poon PM, Thong ML, Higashiuesato Y, Wang X, Kataoka H, Matsubara A, Muliaty D, Kim JH, Watanabe M, Lam CW, Siekmann L, Lopez JB, Panteghinim. The Asian project to collaborative derivation of reference intervals: (1) strategy and major results of standardized analytes.Clin Chem Lab Med2013 Feb 23
17. Wang AYM, Lu Y, Cheung S, Chu M, Wong S, Chan IHS, Lam C-W-K. Plasma sodium and subclinical left atria enlargement in chronic kidney disease.Nephrology Dialysis Transplant 2013 Jan 12.
18. Liu KYP, Hu SQ, Chan BCL, Watt ECL, Lau CBS, Hon KL, Fungi KP, Leung PC, Hui PCL, Lam C-W-K, Wong CK. Anti-inflammatory and anti-allergic activities of Pent herb formula, Mouton cortex (Danni) and Gallic acid.Molecules2013; 18:2483-2500.
19. Qui H, Wong CK, Chu A, Hu SH, Lam C-W-K. Murray deceptive mediated activation of human bronchial epithelial cells interacting with basophiles: a novel mechanism of airway inflammation.Clin Exp Immunol2013; 172:81-94.
20. Li L, Yi T, Lam C-W-K. Interactions between human Multidrug Resistance Related Protein (MRP2; ABCC2) and excipients commonly used in self-emulsifying drug delivery systems (SEDDS).Int J Pharm2013 Feb 22
21. Wang AY, Wang M, Lam CW, Chan IH, Lui SF, Sanderson. JE. Hear failure with preserved or reduced ejection fraction in patients treated with peritoneal dialysis.Am J Kidney Dis2013Mar 6.
22. Wong CK, Hu S, Leung KM, Dong J, He L, Chu YJ, Chu IM, Qiu HN, Liu KY, Lam CW. NOD-like receptors mediated activation of eosinophils interacting with bronchial epithelial cells; a link between innate immunity and allergic asthma. Cell Mol Immunol 2013 Mar 24 [Epub ahead of print].
23. Che CT, Wang ZJ, Chow MSS, Lam CWK. Herb-herb combinations for therapeutic enhancement and advancement: Theory, practice and future prespectives. Molecules 2013; 18:5125-41.
24. Chan MS, Chen Q, Lam CWK. Changes in main causes of death in Macao residents from 1986-2006. Chin Med J 2013; 126: 1661-6.
Published papers (2012)
1. C Liu and T Yi. Research progress of self-assembled beads drug delivery systems prepared from cyclodextrins and oils(环糊精与油制备自组装小珠载药系统的研究进展).ACTA Pharmaceutica Sinica. 2012;47(12):1582-1586.
2. I-H-S Chan, A-P-S Kong, T-F Leung, T-K-C Tsui, R-C-K Cheung, R Osaki, C-S Ho, G-W-K Wong, C-K Wong, C-W-K Lam, J-C-N Chan and M-H-M Chan. Cadmium and lead in Hong Kong school children.Pathology.2012;44(7):626-631.
3. W-J Zhang, Q-L Huang and Z-C Hua. Galangin and TRAIL cooperate to suppress A549 lung cancer proliferation via apoptosis and p38 MAPK activation.ACTA Pharmaceutica Sinica B.2012;2(6):569-574.
4. J-X Chen, W-E Lin, M-Z Chen, C-Q Zhou, Y-L Lin, M Chen, Z-H Jiang and W-H Chen. Synthesis, characterization and potent DNA-cleaving activity of copper(II)-complexedberberine carboxylate.Bioorg Med Chem Lett. 2012;22(23):7056-7059.
5. J Yang, L Li, H Jin, S-Y Tan, J-Y Qiu, L Yang, Y-Q Ding, Z-H Jiang, S-B Jiang and S-W Liu. Vaginal gel formulation based on theaflavin derivatives as a microbicide to prevent HIV sexual transmission.AIDS Res Hum Retroviruses. 2012;28(11):1498-1508.
6. J-Y Yin, Z-H Jiang, H Yu, M-Y Xie, W-L Hsiao, A-P Lu and Q-B Han. A new application of an aqueous diphase solvent system in one-step preparation of polysaccharide from the crude water extract of Radix Astragali by high-speed counter-current chromatography.J Chromatogr A. 2012;1262:92-97.
7. H-Y Zhang, J-R Wang, L-F Yau, H-M Ho, C-L Chan, P Hu, L Liu and Z-H Jiang. A cellular lipidomic study on the Aβ-induced neurotoxicity and neuroprotective effects of EGCG by using UPLC/MS-based glycerolipids profiling and multivariate analysis.Mol BioSyst.2012;8(12):3208-3215.
8. J-R Wang, H Zhou, X-Q Yi, Z-H Jiang and L Liu. Total ginsenosides of radix ginseng modulates tricarboxylic acid cycle protein expression to enhance cardiac energy metabolism in ischemic rat heart tissues.Molecules.2012;17(11):12746-12757.
9. W Fang, F Peng, T Yi , C Zhang, C-X Wan, H-B Xu, C-W-K Lam and X-L Yang. Biological activity and safety ofTripterygium extract prepared by sodium carbonate extraction.Molecules.2012;17(9):11113-11123.
10. R Ding, J-S Tang, H Gao, T Li, H Zhou, L Liu and X-S Yao. New methymycin derivatives ofStreptomyces venezuelaeATCC 15439 and their inhibitory effects on human T cell proliferation mediated by PMA/ionomycin.Arch Pharm Res. 2012;35(9):1567-1572.
11. M Chu, A-Y-M Wang, I-H-S Chan, S-H Chui and C-W-K Lam. Serum small-dense LDL abnormalities in chronic renal disease patients.Br J Biomed Sci. 2012;69(3):99-102.
12. Y Liu, Z-J Su, X Zeng, X Li, Z-F Wu, S-J Xu and Y-Z Yan. Quality assessment of Fructus Xanthii based on metabolism fingerprinting method using high-performance liquid chromatography.J AOAC Int. 2012;95(4):1053-1058.
13. 张文静，黄启来，华子春。木犀草素抑制人肺腺癌A549细胞株的运动及其机制研究 (Luteolin inhibits the motility of human lung adenocarcinoma cell line A549 and its related mechanism)。东南大学学报：医学版。2012; 31(4):415-418。
14. 张文静，黄启来，华子春。高良姜素的生物学活性研究进展。中国医药生物技术. 2012; 7(4):294-297。
15. Z Yang, J-R Wang, T Niu, S Gao, T Yin, M You, Z-H Jiang and M Hu. Inhibition of P-glycoprotein leads to improved oral bioavailability of compound K, an anticancer metabolite of red ginseng extract produced by gut microflora.Drug Metab Dispos. 2012;40(8):1538-1544.
16. A-Y-M Wang and C-W-K Lam. The diagnostic utility of cardiac biomarkers in dialysis patients.Semin Dial.2012;25(4):388-396.
17. S-H Chui, Y-T Szeto and C-W-K Lam. Human papillomavirus infection in Macau women.Public Health.2012;126(7):600-604.
18. X-Y Tian and L Liu. Drug discovery enters a new era with multi-target intervention strategy.ChinJ Integr Med. 2012;18(7),539-542.
19. S-S Wang, K-L Hon, H-Y Sy, A-P Kong, I-H Chan, C-W-K Lam, G-W Wong, J-C Chan and T-F Leung. Interactions between genetic variants of FLG and chromosome 11q13 locus determine susceptibility for eczema phenotypes.J Invest Dermatol. 2012;132(7):1930-1932.
20. Y-F Fan, Y Xie, L Liu, H-M Ho, Y-F Wong, Z-Q Liu and H Zhou. Paeoniflorin reduced acute toxicity of aconitine in rats is associated with the pharmacokinetic alteration of aconitine.J Ethnopharmacol. 2012;141(2):701-708.
21. L Tang, Y Gong, C Lu, L Liu and Z Liu. Pharmacokinetics of aconitine as the target marker of Fuzi (Aconitum carmichaeli) following single and oral administrations of Fuzi extracts in rat by UPLC/MS/MS.J Ethnopharmarcol. 2012;141(2):736-741.
22. Y Gong, Q-L Zha, L Li, Y Liu, B Yang, L Liu, A-P Lu, Y-F Lin and M Jiang. Efficacy and safety of Fufangkuchen colon-coated capsule in the treatment of ulcerative colitis compared with mesalazine: a double-blinded and randomized study. J Ethnopharmarcol. 2012;141(2):592-598.
23. J-R Wang, T Tanaka, H Zhang, I Kouno and Z-H Jiang. Formation and conformation of baicalin-berberine and wogonoside-berberine complexes.Chem Pharm Bull (Tokyo). 2012;60(6):706-711.
24. Y-H Zhao, Y Guan and W-K WU. Potential advantages of a combination of Chinese medicine and bone marrow mesenchymal stem cell transplantation for removing blood stasis and stimulating neogenesis during ischemic stroke treatment.J Tradit Chin Med. 2012;32(2):289-292.
25. H-X Chen and Q-B Wu. Advances in the treatment of prostatodynia with the integrated Chinese and Western medicine.MacauJournal of Chinese Medicine. 2012;(6):72-77.
26. F Sa, W-T Vong, H-H Lo, M-W Chan and C-W-K Lam. Analysis of heavy metals in proprietary Chinese medicines by inductively coupled plasma – mass spectrometry.Journal of MacauUniversity of Science and Technology. 2012;6(1):21-26.
27. L-W Tong and T Yi. Determination of solubility of scutellarin in different pH phosphate buffer solutions by HPLC.Journal of MacauUniversity of Science and Technology. 2012;6(1):16-20.
28. L Li, T Yi and C-W-K Lam. Excipients inhibition of transporters in anticancer nanodrugs. Journal of MacauUniversity of Science and Technology. 2012;6(1):8-15.
29. X-J Li, Y-P Hu, L-G He, S Wang, H Zhou and S-W Liu. Icaritin inhibits T cell activation and prolongs skin allograft survival in mice.Int Immunopharmacol. 2012;13(1):1-7.
30. Z-F Yang, Y-T Wang, S Zhong, S-S Zhao, X-T Zeng, Z-Y Mo, S Qin, W-D Guan, C-Y Li and N-S Zhong. In vitro inhibition of influenza virus infection by a crude extract from Isatis indigotica root resulting in the prevention of viral attachment.Mol Med Report. 2012;5(3):793-799.
31. Z-F Yang, Y-Q Zhan, R-C Chen, R Zhou, Y-T Wang, Y Luo, M Jiang, J-Q Li, S Qin, W-D Guan, K-F Lai, H-L Wen, Z-W Liang, L Li and N-S Zhong. A prospective comparison of the epidemiological and clinical characteristics of pandemic (H1N1) 2009 influenza A virus and seasonal influenza A viruses in Guangzhou, South China in 2009.Jpn J Infect Dis. 2012;65(3):208-214.
32. L Zhu, J-G Lu, T Li, G-Y Zhu, Q-B Han, W-L Hsiao, L Liu and Z-H Jiang. Immunosuppressive decalin derivatives from red yeast rice.J Nat Prod.2012;75(4):567-571.
33. Y-H Zhao, Y Guan, Y-H Xu, Y Li and W-K Wu. Sodium Ferulate combined with bone marrow stromal cell treatment ameliorating rat brain ischemic injury after stroke.Brain Res. 2012;1450:157-165.
34. Y-H Liang, Y-Z Liu, W Bi and G-G Liang. Influence of Ligand structure on the hydrolysis and stability of NAMI derivatives containing 2-methyl imidazole and N-ethyl imidazole.Acta Chim Sinica. 2012;70(7):864-872.
35. W-H Tam, R-C Ma, X Yang, G-T Ko, T-T Lao, M-H Chan, C-W-K Lam, C-S Cockram and J-C Chan. Cardiometabolic risk in Chinese women with prior gestational diabetes: a 15-year follow-up study.Gynecol Obstet Invest. 2012;73(2):168-176.
36. F-G Yan, M Wang, J-M Li, H Cheng, J-J Siu, X-S Wang, H-Y Wu, L-Z Xia, X-X Li, H-C Chang and Q-L Li. Gambogenic acid induced mitochondrial-dependent apoptosis and referred to phospho-Erk 1/2 and phospho-p38 MAPK in human hepatoma HepG2 cells.Environ Toxicol Pharmacol. 2012;33(2):181-190.
37. J Yang, L Li,S-Y Tan, H Jin, J-Y Qiu, Q Mao, R Li, C Xia, Z-H Jiang, S-B Jiang and S-W Liu. A natural theaflavins preparation inhibits HIV-1 infection by targeting the entry step: potential applications for preventing HIV-1 infection.Fitoterapia. 2012;83(2):348-355.
38. L Feng, Y-H Xu, S-S Wang, W Au-yang, Z-G Zheng, R-S Wang, Q Zhu and P Xiang. Preventative effects of 4,4'-diphenylmethane-bis(methyl) carbamate isolated from cortex mori on human umbilical vein endothelial cell dysfunction induced by advanced glycation end products.Phytother Res. 2012;26(3):412-419.
39. H-Y Zhang, H-H Yang, M Zhang, Y-R Wang, J-R Wang, L-F Yau, Z-H Jiang and P Hu. Identification of flavonol and triterpene glycosides in Luo-Han-Guo extract using ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry.J Food Comp Analy. 2012;25(2):142-148.
40. R-R Fiscus, E-L-H Leung, J-C Wong and M-G Johlfs.Nitric Oxide/Protein Kinase G-Iα Promotes c-Src Activation, Proliferation and Chemoresistance in Ovarian Cancer. Overian Cancer- Basic Science Perspective, Samir Farghaly (Ed.), Intech Open Access Publisher. Chapter 16, 315-334.
41. H He, L-P Bai and Z-H Jiang. Synthesis and human telomeric G-quadruplex DNA-binding activity of glucosaminosides of shikonin/alkannin.Bioorg Med Chem Lett.2012;22(4):1582-1586.
42. L Zhu, L-F Yau, J-G Lu, G-Y Zhu, J-R Wang, Q-B Han, W-L Hsiao and Z-H Jiang. Cytotoxic dehydromonacolins from red yeast rice.J Agric Food Chem. 2012;60(4):934-939.
43. Q-L Huang, C-G Gong, J-H Li, Z Zhou, Y Chen, J Wang and Z-C Hua. Distance and helical phase dependence of synergistic transcription activation in cis-regulatory module.PloS One. 2012;7(1):e31198.
44. C-K Wong, K-M-L Leung, H-N Qiu, J-Y-S Chow, A-O-K Choi and C-W-K Lam. Activation of eosinophils interacting with dermal fibroblasts by pruritogenic cytokine IL-31 and alarmin IL-33: implications in atopic dermatitis.PLoS One. 2012;7(1):e29815.
45. L Feng, Y-H Xu, S-S Wang, W Au-yeung, Z-G Zheng, Q Zhu and P Xiang. Competitive binding between 4,4'-diphenylmethane-bis(methyl) carbamate and RAGE ligand MG-H1 on human umbilical vein endothelial cell by cell membrane chromatograph.J Chromatogr B Analyt Technol Biomed Life Sci. 2012;881-882:55-62.
46. 张鹏，黄启来，华子春。荜茇酰胺的药理作用研究进展 (Advances in studies on pharmacological effects of piperlongumine)。中草药。2012;43(1):201-204。
47. Vong WT, Lam WK. Analysis of melamine in pre-packaged food by gas chromatography - mass spectrometry. Journal of Macau University of Scinece and Technology 2012;6:50-6.