Apparatuses for Pharmaceutical Nano-technology Studies

Laboratory for New Formulation Technology of Chinese Medicinal Preparations

BÜCHI Mini Spray Dryer B-290 Spray Dryer

Introduction:

lMaximum drying capacity: 1 L water/hour

lDrying duration: 1.0 – 1.5 seconds

lMaximum air flow rate: 35 m³/hour

lMaximum drying temperature: 220 ^oC

lLED digital display at inlet temperature, outlet humidity, ventilator wind speed, peristaltic pump flow rate.

lWith inert gas accessory B295 for spray drying organic solvent.

lAutomatic online nozzle cleaning.

lMinimal sample volume: 20-50 ml

Laboratory for New Formulation Technology of Chinese Medicinal Preparations

Extrusion/Spheronization Multi-purpose extrusion, spheronization, coating system

Introduction:

lEquipped with extrusion/spheronization, drying and coating functions. Useful for the preparation of pellets by extrusion-spheronization, together with spray coating for the manufacture of protective coating, enteric coating or delay-release coating and drug delivery.

lUnique temperature control system.

lPore plate with different size for the preparation of 0.1 – 0.3 mm small pellet.

lPrecise control in coating temperature. Good quality in atomizer. Reliable quality in coating. Modular structure for easy cleaning and GMP compliance.

Laboratory for New Formulation Technology of Chinese Medicinal Preparations

Mini Glatt Fluid Bed Processor

Introduction:

lFor drying, pelletization and coating in small laboratory scale.

lDual atomizer nozzle for pelletization and coating.

lMinimal processing amount at 2.5 – 10 grams with Micro-Kit

Laboratory for New Formulation Technology of Chinese Medicinal Preparations

Microfluidics M-110P High Pressure Microfluidizer

Introduction

lFor the small scale preparation of nano-crystal and liposome.

lMaximal working pressure at 30,000 psi; normal flow rate at 110 – 155 ml/min; smallest fluidic volume at 25 ml.

lThe contact surface for the fluid is corrosive-resistance 316 stainless steel and other specialized material.

lEquipped with hydraulic pump. Manual control of pressure and valve. Automatic control of oil hydraulic pump.

Laboratory for New Formulation Technology of Chinese Medicinal Preparations

APV-2000 Homogeniser

Introduction

lFor crushing solid pellet into extremely small pieces, and the preparation of reproducible nano-scale dispersion solution.

lFor the preparation of nano-scale emulsion and liposome.

lMaximal operating pressure at 2,000 bars with minimal volume at 50 ml.

Laboratory for New Formulation Technology of Chinese Medicinal Preparations

Malvern Zetasizer NanoZS90

lMeasurement of particle size Zeta potential in dispersion solution from 0.3 nm to 5 m.

lZeta potential measurement from 3.8 nm to 100 m.

lParticulate concentration range from 0.1 ppm (0.00001 v/v %) – 40 wt%.

Laboratory for New Formulation Technology of Chinese Medicinal Preparations

ERWEKA Dissolution Tester Offline System 

Introduction

lAutomated sampling system for replenishment of withdrawn media

lUnique design to prevent evaporation and contamination from withdrawn media

lAutomated adjustment of dissolution container

lAutomated dosing arm for testing of sample at the preset temperature

Laboratory for New Formulation Technology of Chinese Medicinal Preparations

Pharma-test Automated PTG S3 Powder Testing System

Introduction

lDetermination of sample powder flow time, powder volume, density, angle of repose, fluidity of 100 mg samples, total sample weight in a defined time window, and sample flow chart in mg/time

lAngle of repose from 1.0^o to 45.0^o

lFluidity test range from 0.1 s to 999 s for 100 grams sample

lPowder density from 0.000 g/ml to 6.0 g/ml

lPowder weight from 1 mg to 325 g

lPowder volume from 0.1 ml to 275 ml

Laboratory for New Formulation Technology of Chinese Medicinal Preparations

ERWEKA USP 4 Close-loop Dissolution Tester Offline System

Introduction:

• The system is capable of performing dissolution experiment on different formulation based on the principle of U.S. Pharmacopeial Convention (USP) apparatus 4 (Flow-through cell).

• Flow-through cell is an improvement to the traditional dissolution testing method. As a USP apparatus, the system meets the requirement of all existing analytical method. By changing the flow-through cell and flow rate of dissolution media, the system can be used to analyze novel and complex formulation.

• Flow-through cell is recommended by USP for the determination of difficult-to-dissolve and sustained release drug. These drugs required a large volume of dissolution media, which is limited by the traditional USP stirring method. On the other hand, flow-through method has no limitation on dissolution volume, which makes it ideal to overcome the harsh sink condition with larger dissolution volume.

• Because of the supply of fresh media, capability of changing pH value rapidly and continuous sampling, flow-through method provides consistent sink condition.