Date: 26th May 2026 (Tuesday)

Time: 17:00 – 18:00

Venue: N317

Theme: MSD Research Seminar Series- “Nanoaggregates Mediated Nanosecond Pulsed Electric Field for Enhanced Anti-HCC via Strengthened Interaction between Regulated pan-Cell Death and Immune Remodeling”

Language: Mandarin

Speaker’s Biography

Dr. Song Yujuan is currently a Professor in the Department of Applied Physics at University of Science and Technology Beijing, Deputy Director of the Center for Modern Physical Technology Research, and a Council Member of the Chinese Micro-Nano Technology Society, Associate Editor of Coatings and Editorial Member of Sci Rep. He worked for 8 years at the Advanced Microstructure and Devices Center of Louisiana State University as one Permanent Research Associate, the Applied Research Center at Jefferson Lab of Old Dominion University.

His research focuses primarily on the key physical and chemical mechanisms and application technologies of Superatomic nanoaggregates regulated by surface and interface engineering and Intense Power Pulsed Physical Field for biomedicine, new energy, industrial catalysis, and quantum information technologies. As a project leader, Dr. Song has presided over more than 30 scientific research funds, including national major science and technology special projects, general projects of the National Natural Science Foundation of China. Dr. Song has published over 100 peer-reviewed SCI papers, obtained 33 authorized patents, and edited 5 monographs and 1 textbook.

Research interests

Microfluidic controllable synthesis; Nanofunctional materials; Tailings resource utilization; Field-controlled programmed fabrication techniques; Template-assisted physical methods in energy catalysis, biomedicine, and magneto-optical information technology

Seminar Introduction

This study develops a combined cancer therapy approach by nanoaggregates (NAs) mediated nanosecond pulse electric field ablation (nsPEFA). Using the NAs model and orthotropic hepatocellular carcinoma (HCC) as the pathological model, the anti-cancer efficacy and its related molecular mechanisms were investigated, focusing on how enhanced pan-regulatory cell death (PAN-RCD) and immune remodeling interactions reinforce anti-cancer effects. Based on single-cell and tissue section tumor imaging, serum chemokine analysis, and histopathological staining, the combined therapy is capable of eliminating cancer cell escape during surgery and inhibiting postoperative tumor metastasis and recurrence at different stages of HCC, including early and late stages. Analysis of pathological sections of key organs and chemokines from sacrificed mice confirmed that the combined therapy also markedly improves biosafety, characterized by reduced adverse reactions from monotherapies, with no obvious translocation, damage, or retention of NAs in key organs. Further analysis of the therapeutic mechanism confirmed the multi-dimensional synergistic effects between nsPEFA and NAs: in situ electro-poration and polarization of cell membranes and contents by nsPEFA, enhanced cellular internalization of NAs mediated by nsPEFA, complementary improvement of organ dysfunction caused by nsPEFA or NAs used alone, and the induction of multimodal PAN-RCD (e.g., apoptosis, ferroptosis, mitochondrial dysfunction-induced apoptosis, pyroptosis-like membrane rupture, necroptosis) along with enhanced immune response activation by the combined therapy.

Students who are interested should register on WeMust-Event.

All research staff and students are welcome to attend this seminar.

For more inquiries, please contact (853) 8897 3411 or email [email protected]